The new FPS High Containment isolator for Micronization

July 15, 2020

In recent years more companies working with High Potent APIs are asking for high flexibility and a very low containment level at the same time. Relying on almost 2 decades of experience, continuous improvement and 100% in-house manufacturing, FPS is now the leader for containment and micronization systems.

The latest challenge was to design a multi-purpose isolator used to micronize down to a few microns covering a wide range of batch size and assuring a Containment Performance Target (CPT) of 50ng/m3. Inside the isolator, a 4”, 8” or 12” jet mill can be used. To achieve this, a 9-chamber isolator has been designed (with 2 platforms to work at 3 different levels). It is one of the biggest isolators installed in the USA. The design of the isolator follows best ergonomic principles, and is optimized to significantly reduce the maintenance and cleaning time. For example, in the 4” jet mill configuration, only 3 of the 9 chambers are used. This significantly reduces cleaning, turn over time and reduces operating costs. The machine is fully automated with a centralized control system and HMI touchscreen panel.

The software is developed in-house, fully customized to the customer needs and optimized to be user-friendly. The project has been developed starting from the GA and P&ID drawings, going through a full-week mock up tests and then the Factory Acceptance Test (FAT). The installation and validation activities are executed by the FPS customer service team.

“For us at FPS it was an important project”, underlines Eng. Sebastiano Mancarella, FPS Sales Manager, “we are proud to have accepted this new challenge and to have successfully faced it together with the customer. Our FPS never stops motto is the demonstration that we like to innovate and find optimal solutions for our customers. It also shows how we like to offer a very personalized service to each customer.”