When handling HPAPI or intermediates, all operations in chemical reactors, filters, centrifuges, and dryers must be carried out under absolute containment for the protection of the operator.
The isolation system is designed according to the size of the process equipment and to enclose the system completely or, in some cases, contain only the parts where product transfer occurs.
FPS has gained in-depth knowledge of these types of systems and is able to design customized systems according to customer needs.
Typical applications are:
How to safely discharge a Spray Dryer and mill the potent API? Process: Feed slurry into the Spray Dryer, collect the potent dry powder, micronize if necessary, weight and dispense (for pilot application: max 5 kg) What are the issues? Staff comes in and out of the lab very frequently: Each time they lose 3 […]
How can a lab safely weight & dispense toxic APIs and liquid solutions? How to get more protection than the current flexible isolator? Process steps Introduce bags of potent API, weight & dispense in smaller bags Bring in flasks, add solution and dispense in smaller flasks Test samples of potent powder or liquid Challenges of […]
How can you transfer potent in-process API from a filter dryer into drums or big bags? Process: Transfer potent in-process API from a filter dryer into drums or big bags What are the issues: Api is highly toxic (OEL 10 µg/m3) Powder can agglomerate and not flow: Power can clog and stop the process Once […]
A new multipurpose High Potent API facility needed a containment solution for pilot production. It already owned a few pieces of process equipment. To have those integrated in an isolator could be tricky. Here is a summary of the issues they faced and the solutions implemented by FPS (2 mn read) Process: To filter Highly Potent […]
