Pack-Off 10 µg/m3

How can you transfer potent in-process API from a filter dryer into drums or big bags?

Process:

• Transfer potent in-process API from a filter dryer into drums or big bags

What are the issues:

• Api is highly toxic (OEL 10 µg/m3)
• Powder can agglomerate and not flow:
  • Power can clog and stop the process
  • Once in large drums/bags the powder can easily agglomerate
  • It will create problems for the next step of the chemical process
• Particle size can be uneven: there could be some abnormally large particles

Benefits of FPS Solution:

• No risk of exposure for the operators
• Process is automated:
  • High productivity (over 50% faster and mistake proof)
  • 100% weighting accuracy
• Automatic CIP system guarantees highly efficient cleaning
  • No risk of cross contamination after product change over
• Flexibility: powder can be fed to various sizes of drums or big-bags (with use of adaptors)

Description of FPS solution:

• Process is closed off
  • Cleaning time is reduced by 90%
• An automated coarse dosing valve is clamped at the filter dryer discharge pipe
  • provides a consistent feed to a cone mill
• In-line cone mill breaks down large particles:
  • Powder will flow more easily
  • Narrower particle size distribution: facilitates the downstream process
• An automated fine dosing valve speeds up reaching the accurate weight
• Milled powder is fed into drums through a continuous liner or big bags with safe-change feature
  • Closed system: no powder floating in the air
  • Safe process for operators: no need for PPEs (better ergonomics and avoids losing 1hour per shift for gowning/degowning)
• Automatic weighting system controlled by FPS-designed central PLC:
  • High accuracy & repeatability
  • High productivity
• CIP cleaning can use aggressive solvents (system is Explosion-Proof designed)
• 1 central control system to operate all the equipment & control the cleaning