First of all, the design team must fully understand the process and have a lot of experience integrating various kinds of processing equipment into isolators. The design must be committed to build the custom isolator around your process and not the other way around.
This requires a deep collaboration with the customer and a very open and honest dialog.
Finally to find the best configuration for the machine, the optimum location for the instruments and accessories you can’t stop at the 3D CAD model.
An ergonomic study with a wooden mock-up at scale is a crucial step to try out the isolator and reach the best final design in terms of containment performance and ergonomics.