An isolator is an enclosed and confined system designed for handling toxic substances, pharmaceuticals or pathogens and capable of isolating and protecting the operator, the environment and the product. Containment systems enable the operator to work with highly toxic powders (HAPI and HPAPI) or sterile powders in a safe and efficient manner: they work under negative pressure, that is, they prevent the material processed inside from being released outside to ensure that the operator handles the powders in a fully safe manner and prevent the toxic substances from escaping into the surrounding environment. An aseptic isolator provides a completely sterile environment for carrying out aseptic processes, i.e., aseptic handling of active ingredients, in order to maintain constant sterility of the product being handled.