1. Micronization
  2. Spiral jet mill

Spiral jet mill

With spiral jet mill technology the size reduction is achieved by collisions between particles of the substance, previously accelerated by high-speed jet streams. Target PSD is generally below 30μm when adopting this technology.

The main advantages are represented by:

  • Easy Cleaning for Validation (to avoid cross contamination)
  • No mechanical parts in movement (no lubrication, strong reduction of metallic contamination)
  • No Heat Generation 
  • Constant Temperature 

Working principle​

  • High pressure gas (typically Air or Nitrogen), from 2 up to 12 barg
  • Product particles acceleration in the milling chamber
  • Particle to particle collision for product fragmentation
  • Static classification

R&D Units

The R&D Jet Mill series is engineered to meet the requirements of R&D labs, where new product are developed and micronization process is requested on small quantities (from minimum 10mg to 100g).

The R&D Jet Mil series belongs to a jet mill family which is the result of an unparalleled optimization study. All connections of components are made to be in compliance with cGMPs and to assure quick and easy assembling and disassembling operations. The number of components is reduced at minimum in order to speed up also cleaning and validation activities.

The R&D Jet Mil series may be easily integrated into FPS isolators to allow the process of very high active or sterile products.

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LaboMill-0

R&D Milling machine for Pharmaceutical, chemical, cosmetic and food activities - PM0

LaboMill-0 represents the right solution for preliminary feasibility micronization trials with milligrams batches of New Chemical Entities, as well as of many other products.

  • Based on the proven FPS Spiral Jet Mill technology
  • Designed to effectively operate despite the miniaturized dimensions
  • Maintaining a high performance level and reliability

As per the trials performed in our laboratory using Lactose:

  • 10mg is minimum batch micronized with PilotMill-Zero
  • Recovered product: 190mg (95% of yield on 200mg batch)

At FPS R&D and Test Centre it is possible to perform technical trials with your products and LaboMill-0.

PDF icon PilotMill-Zero - Technical Data sheet 04.14
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LaboMill-1

The LaboMill-1 is the FPS answer to R&D lab needs when it comes to very initial stages of development, when only extremely small "batch sizes" are available. This very limited amount of material - starting from 200 mg - asks for the use of very special equipment designed and developed via a "miniaturization" process.

Despite the reduced dimensions, the LaboMill-1 are able to assure full scalability of micronization process with other FPS jet mills.

The LaboMill-1 jet mills may be easily integrated within a FPS isolator system for the safe handing and processing of high potent API or toxic products.

PDF icon labomill1-07.20_lr.pdf
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Pilot Units

The PilotMill series is able to meet the request for laboratory needs and small production batch sizes (from 3g to 100kg).

The PilotMill series belongs to a jet mill family which is the result of an unparalleled optimization study.All connections of components are made to be in compliance with cGMPs and to assure quick and easy assembling and disassembling operations. The number of components is reduced at minimum in order to speed up also cleaning and validation activities.

The PilotMill  series jet mills may be easily integrated into FPS isolators to allow the process of very high active or sterile products.

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PilotMill-2

The PilotMill-2 jet mill is designed for product research and developments needs, where batches from 1g to 3kg are considered. In function of these process condition, the PilotMill-2 jet mill has been designed to assure higher micronized product yield. It is available in top discharge configuration with product recovery inside the filtering bag to further maximise product yield.

The PilotMill-2 jet mill may be easily integrated into glove box systems to allow the process of very high active or sterile products. It’s also available in ATEX configuration. Special configuration i.e. with PTFE or ceramic inserts/lining, in Hastelloy and others are available upon request.

PDF icon PilotMill-2 - Technical Data Sheets 04.14
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PilotMill-3

Pilot unit milling machine for Pharmaceutical, chemical, cosmetic and food activities - PilotMill-3

The PilotMill-3 jet mill still more indicated for R&D activities, can start micronizing batch sizes as low as 3g with extremely contained product loss and can micronize batches up to approx. 10kg. 

The PilotMill-3 jet mill may be easily integrated into glove box systems to allow the process of very high active or sterile products. It’s also available in ATEX configuration. Special configuration i.e. with PTFE or ceramic inserts/lining, in Hastelloy and others are available upon request.

PDF icon Pilot Mill 3 - Technical Data Sheet 04.14
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PilotMill-4

The PilotMill-4 jet mill is designed for product developments needs, where batches from 5g to 60kg are considered. 

The PilotMill-4 jet mill may be easily integrated into glove box systems to allow the process of very high active or sterile products. It’s also available in ATEX configuration. Special configuration i.e. with PTFE or ceramic inserts/lining, in Hastelloy and others are available upon request.

PDF icon PilotMill-4 - Technical Data Sheet 04.14
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PilotMill-5

Pilot unit milling machine for Pharmaceutical, chemical, cosmetic and food activities - PilotMill-5

The PilotMill-5 jet mill is designed for product developments needs and small production campaigns, where batches from 100g to 100kg are considered. The PilotMill-5 jet mill may be easily integrated into glove box systems to allow the process of very high active or sterile products. It’s also available in ATEX configuration.

Special configuration i.e. with PTFE or ceramic inserts/lining, in Hastelloy and others are available upon request.

PDF icon PilotMill-5 - Technical Data Sheet 07.16
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PilotMill-6

The PilotMill-6 jet mill is designed for product developments needs and small production campaigns, where batches from 500g to 250kg are considered.

The PilotMill-6 jet mill may be easily integrated into glove box systems to allow the process of very high active or sterile products. It’s also available in ATEX configuration.

Special configuration i.e. with PTFE or ceramic inserts/lining, in Hastelloy and others are available upon request.

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Production Units

The ProMill series is engineered to encounter the request from production facilities, where large volumes are processed in a flexible and efficient operation.

The ProMill series belongs to a jet mill family which is the result of an unparalleled optimization study. This optimization brings FPS Jet mill to low process gas consumption, to process performances and yields, quick product change operations.

All connections of components are made to be in compliance with cGMPs and to assure quick and easy assembling and disassembling operations. The number of components is reduced at minimum in order to speed up also handling, cleaning and validation activities. The ProMill  series jet mills may be easily integrated into FPS isolators to allow the process of very high active or sterile products.

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ProMill-8

The ProMill-8 jet mill is designed for production needs. The typical batch sizes is between 2kg and 1000kg. It’s available in two configurations, cosmetic/chemical and pharmaceutical, to better-fit different requirements.

At FPS R&D and test center it’s possible to perform technical trials with products on ProMills.

ProMill-8 unit is available in:

- ATEX configuration

- with PLC control system

- with interchangeable inserts (AISI316L, HC-22, PTFE, HDPE or ceramic)

- WIP /CIP

PDF icon ProMill-8 - Technical Data Sheet 04.14
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ProMill-12

Production unit milling machine for Pharmaceutical, chemical, cosmetic and food activities - ProMill-12

The ProMill-12 jet mill is designed for production needs. Typical batch sizes is between 5kg and 2500kg. It is available in two configurations, chemical and pharmaceutical, to better-fit different requirements.

At FPS R&D and test center it’s possible to perform technical trials with products on ProMills.

ProMill-12 unit is available in:

- ATEX configuration

- with PLC control system

- with interchangeable inserts (AISI316L, HC-22, PTFE, HDPE or ceramic)

- WIP /CIP

PDF icon ProMill-12 - Technical Data Sheet 04.14
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ProMill-16

Production unit milling machine for Pharmaceutical, chemical, cosmetic and food activities - ProMill-16

The ProMill-16 jet mill is designed for production needs. Typical batch sizes is between 20kg and 5000kg. It is available in two configurations, chemical and pharmaceutical, to better-fit different requirements.

At FPS R&D and test center it’s possible to perform technical trials with products on ProMills.

ProMill-16 unit is available in:

- ATEX configuration

- with PLC control system

- with interchangeable inserts (AISI316L, HC-22, PTFE, HDPE or ceramic)

- WIP /CIP

PDF icon ProMill-16 - Technical Data Sheet 04.14
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