The R&D jet mill series is engineered to meet the requirements of R&D labs, where new products are developed and micronization process is requested on small quantities (from minimum 10mg to 100g).
These series belong to a jet mill family which is the result of an unparalleled optimization study. All connections of components are made to be in compliance with cGMPs and to assure quick and easy assembling and disassembling operations. The number of components is reduced at minimum in order to speed up also cleaning and validation activities.
The R&D jet mills may be easily integrated into FPS isolators to allow the process of very high active or sterile products.
| Name | labo mill - 0 | labo mill - 1 / PM1 |
|---|---|---|
| Dimensions | 3/4 " milling chamber | 1" 1/2 milling chamber |
| Material | AISI316L for product contact parts | AISI316L / PTFE / superlattice |
| Gaskets | Silicone -FEP | PTFE - FEP / viton - silicone |
| Surface roughness | # | < 0,25 μm - contact parts < 0,80 μm - non contact parts |
| Surface finish | mirror polished | |
| Batch Size | minimum 10 mg - maximum 100 mg | minimum 0,2 g - maximum 100 g |
| Productivity | # | minimum 3 g/h - maximum 80 g/h |
| Gas Consumtpion @ 7 barg | 0,67 Nm3/h | 5,0 Nm3/h |
| Gas Consumtpion @ 12 barg | 1,15 Nm3/h | 8,6 Nm3/h |
| Gas Consumtpion @ 100 psig | 0,42 SCFM | 3,1 SCFM |
| Gas Consumtpion @ 175 psig | 0,72 SCFM | 5,4 SCFM |
| Utilities | 4 mm connection - Air / nitrogen | |
| Yield | 75% (batch 10 mg) - 82% (batch 20 mg) 95% (batch 200 mg) | 88% (batch 0,2 g) - 99,8% (batch > 20 g) |
| Working pressure | from 1 up to 6 barg | from 2 up to 12 barg |
The LaboMill-0 is the first world smallest fluid jet mill. It can be used for initial development studies of a pharmaceutical molecule, to test the applicability of the micronization process, and to increase the specific surface area of molecules under development that are available in limited quantities.
LaboMill-0 represents the right solution for preliminary feasibility micronization trials with milligrams batches of New Chemical Entities, as well as of many other products.
The system is based on the proven FPS Spiral Jet Mill technology and it’s designed to effectively operate despite the miniaturized dimensions and to maintaining a high performance level and reliability.
At FPS MEC test Center it is possible to perform technical trials with your products and LaboMill-0.
LaboMill-1 / Pm1 are laboratory micronizers, used especially in the early stages of development and when only extremely small batch sizes are available. The very limited amount of material (as low as 200 mg) requires the use of very special equipment designed and developed earlier through a “miniaturization” process. But despite the small size, LaboMill-1 and Pm1 are able to ensure full scalability of the micronization process.
LaboMill-1 allow a discharge configuration from below while PM1 a top discharge configuration where product recovery inside the filter bag.
LaboMill-1 and Pm1 jet mills can be easily integrated within an FPS isolator system for the safe handling and processing of APIs or toxic products.
Early drug development is increasingly important, and FPS supports that activity by offering new custom solutions that fit the specific needs of the Pharmaceutical, Biotech and Fine Chemical sectors. What do we mean by isolators for R&D and Pilot Plants? These machines are installed in research laboratories and/or pilot production plants, to ensure safe handling of active substances in […]
FPS has recently cooperated with pharmaceutical industry experts to research best jet mill practices for pharmaceutical. FPS strongly believes in knowledge sharing and continuous improvement. For this reason, FPS President, Eng. Gianola, and Vice President, Mr Corsini, both experts in milling and micronization technologies, worked with M. Nakach Ph.D on a research published in the Pharmaceutical Development and Technology Magazine. Mr. Nakach works at Sanofi. He […]
FPS is alongside its customers too after system installation and validation and offers them a specific replacement service set off. Our team of experts is able to provide customized spare parts lists to plan the periodic replacement of parts subject to wear, managing the entire life cycle of spare parts. We have decided to dedicate […]
Issues: Particle size reduction down to low micron is needed Operators must be protected because product is very dusty Large campaigns with expensive product: highest productivity is needed High Potent apis will be added in the future “High Potent Ready” solution: Air-tight separation cyclone with WIP to contain dust Modular micronization equipment for easy integration […]
